Many people, myself included, use EpicTable for maps and handouts even in face-to-face games.
I used to print out pictures of cool locations or monsters to show to the players at the table, and now I just use EpicTable. It saves a lot of time and ink. Sometimes I'll use the actual handouts feature, and sometimes I just create a tabletop, give it a background appropriate to my game, and put images on the tabletop.
EpicTable maps have pretty much made my dry-erase battlemat obsolete. I used to have to call a halt to the game while I drew out an area (because pre-drawn dry erase maps tend to either get smudged or become permanent). Now, I just prep my maps ahead of time and share them when the encounter occurs. I like this because it's faster, but also because we get to play on beautiful maps, rather than on my hand-drawn dry-erase battlemat. Also, if we have to stop or take a break, the position of everything is saved.
Using Multiple Screens
When I'm using EpicTable for face-to-face games, I always use a separate screen for the players, so I have my GM's screen on the laptop and the player screen on a second monitor. Since EpicTable maps support touch, I use a touch-enabled monitor for my second screen, so I can draw on the map or move things around directly on the monitor.